Sculptra® is approved by the FDA for restoration and/or correction of the signs of facial fat loss, or lipoatrophy, in people with human immunodeficiency virus. Areas of the Face Treated with Sculptra® in Clinical Studies In a clinical study, the effects lasted for up to 2 years after the first treatment session in most patients. The results from Sculptra® are not immediate; Sculptra® provides a gradual increase in skin thickness. Your doctor will determine the number of additional injections needed. Sculptra® is a safe, synthetic, and biocompatible material that is injected below the surface of the skin in the area of fat loss. It provides a gradual and significant increase in skin thickness, improving the appearance of folds and sunken areas. No skin testing is required.